The host tRNA epitranscriptome: A new player in RNA virus infections
نویسندگان
چکیده
Viruses completely depend on the host translation machineries to express viral proteins. Recent data reveal an unprecedented interaction of positive strand RNA ((+)RNA) viruses with tRNA epitranscriptome favor protein expression via a specific reprogramming codon optimality that ultimately favors decoding codons. We propose this feature is shared by multiple and involved modifying enzymes represent promising novel targets for development broad-spectrum antivirals.
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ژورنال
عنوان ژورنال: Frontiers in virology
سال: 2022
ISSN: ['2673-818X']
DOI: https://doi.org/10.3389/fviro.2022.1073619